Distribution of tritiated tetrodotoxin administered intraperitoneally to pufferfish.

  title={Distribution of tritiated tetrodotoxin administered intraperitoneally to pufferfish.},
  author={Shugo Watabe and Yuko Sato and Mitsuo Nakaya and Norio Nogawa and Kenichi Oohashi and Tamao Noguchi and Nobuo Morikawa and Kenji Hashimoto},
  journal={Toxicon : official journal of the International Society on Toxinology},
  volume={25 12},
Tetrodotoxin was recoil-tritiated by the 3He(n,p)3H reaction and purified by gel filtration. The [3H]tetrodotoxin gave only one spot in both cellulose acetate strip electrophoresis and thin layer chromatography. The specific toxicity of tetrodotoxin did not decrease during the recoil tritiation and the [3H]tetrodotoxin showed a specific radioactivity of 25 x 10(-6) Ci/mmole. In spite of the low specific radioactivity, the [3H]tetrodotoxin was able to be used to investigate the anatomical… CONTINUE READING
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