Distribution of the zinc transporter ZnT-1 in comparison with chelatable zinc in the mouse brain.

@article{Sekler2002DistributionOT,
  title={Distribution of the zinc transporter ZnT-1 in comparison with chelatable zinc in the mouse brain.},
  author={Israel Sekler and Arie Moran and Michal Hershfinkel and Amir Dori and Ariel Margulis and Nurit Birenzweig and Yuval Bibi Nitzan and William F. Silverman},
  journal={The Journal of comparative neurology},
  year={2002},
  volume={447 3},
  pages={201-9}
}
Zinc maintains a diverse array of functions in the mammalian central nervous system as a key component of numerous enzymes, via its role in the activation of transcription factors, and as a neuroregulator, modulating neuronal receptors such as N-methyl-D-aspartate and gamma-aminobutyric acid. Zinc has a dark side, however, with massive influx of Zn(2+) to neurons considered to be a key factor in neuronal death secondary to ischemia and seizure. Several different putative zinc transporters, ZnT… CONTINUE READING
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