Distribution of the molecular forms of acetylcholinesterase in human brain: alterations in dementia of the Alzheimer type.

@article{Fishman1986DistributionOT,
  title={Distribution of the molecular forms of acetylcholinesterase in human brain: alterations in dementia of the Alzheimer type.},
  author={Elizabeth Fishman and G C Siek and R. M. MacCallum and Edward D. Bird and Ladislav Volicer and Judith K. Marquis},
  journal={Annals of neurology},
  year={1986},
  volume={19 3},
  pages={246-52}
}
Acetylcholinesterase (AChE), the enzyme that degrades acetylcholine, is a heterogeneous enzyme that can be separated into multiple molecular forms. A tetrameric membrane-bound form (G4) and a monomeric soluble form (G1) are the two predominant enzyme species in mammalian brain. The distribution of AChE molecular forms was defined by sucrose density gradients of 11 anatomical regions of postmortem brains from 10 patients with dementia of the Alzheimer type (DAT) and 14 nondemented controls of… CONTINUE READING

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