Distribution of the granulocyte serine proteinases proteinase 3 and elastase in human glomerulonephritis.

@article{Mrowka1995DistributionOT,
  title={Distribution of the granulocyte serine proteinases proteinase 3 and elastase in human glomerulonephritis.},
  author={Ch. Mrowka and Elena Csernok and Wolfgang Ludwig Gross and Helmut E. Feucht and Ulrike Bechtel and Gunther H. Thoenes},
  journal={American journal of kidney diseases : the official journal of the National Kidney Foundation},
  year={1995},
  volume={25 2},
  pages={253-61}
}
The serine proteinases proteinase 3 (PR3) and elastase are target antigens of antineutrophil cytoplasmic autoantibodies (ANCAs), which are found in various systemic vasculitides with rapidly progressive glomerulonephritis (RPGN). The expression of both proteinases was studied immunohistologically (avidin-biotin complex method) with murine monoclonal antibodies against PR3 (WGM2) and elastase (NP 57) in 122 human renal biopsy specimens to investigate their role in mediating renal damage… CONTINUE READING

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