Distribution of the cystine/glutamate antiporter system xc- in the brain, kidney, and duodenum.

@article{Burdo2006DistributionOT,
  title={Distribution of the cystine/glutamate antiporter system xc- in the brain, kidney, and duodenum.},
  author={Joseph Burdo and Richard Dargusch and David Schubert},
  journal={The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society},
  year={2006},
  volume={54 5},
  pages={
          549-57
        }
}
System x(c)(-), one of the main transporters responsible for central nervous system cystine transport, is comprised of two subunits, xCT and 4F2hc. The transport of cystine into cells is rate limiting for glutathione synthesis, the major antioxidant and redox cofactor in the brain. Alterations in glutathione status are prevalent in numerous neurodegenerative diseases, emphasizing the importance of proper cystine homeostasis. However, the distribution of xCT and 4F2hc within the brain and other… CONTINUE READING

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