Distribution of the CTLA-4 single nucleotide polymorphisms CT60G>A and +49A>G in psoriasis vulgaris patients and control individuals from a Polish Caucasian population.

@article{uszczek2007DistributionOT,
  title={Distribution of the CTLA-4 single nucleotide polymorphisms CT60G>A and +49A>G in psoriasis vulgaris patients and control individuals from a Polish Caucasian population.},
  author={Wioleta Łuszczek and Edyta Majorczyk and Piotr Nockowski and Piotr Plucinski and Monika Jasek and Izabela Nowak and Andrzej Wisniewski and Piotr Kuśnierczyk},
  journal={International journal of immunogenetics},
  year={2007},
  volume={35 1},
  pages={
          51-5
        }
}
Psoriasis vulgaris is a multifactorial disease with an autoimmune component, and T lymphocytes seem to be involved in its aetiology. CTLA-4 molecule is an important down-regulator of T-lymphocyte activation, and several polymorphisms of the CTLA-4 gene were found to be associated with some autoimmune diseases. We examined whether single nucleotide polymorphisms (SNPs) in the CTLA-4 gene, CT60A>G and +49A>G, are associated with psoriasis vulgaris. Alleles of these two SNPs were determined by the… CONTINUE READING