Distribution of the 5-HT1A receptor antagonist [18F]FPWAY in blood and brain of the rat with and without isoflurane anesthesia

@article{Tokugawa2006DistributionOT,
  title={Distribution of the 5-HT1A receptor antagonist [18F]FPWAY in blood and brain of the rat with and without isoflurane anesthesia},
  author={Joji Tokugawa and L. Ravasi and T. Nakayama and L. Lang and K. Schmidt and J. Seidel and M. Green and L. Sokoloff and W. Eckelman},
  journal={European Journal of Nuclear Medicine and Molecular Imaging},
  year={2006},
  volume={34},
  pages={259-266}
}
  • Joji Tokugawa, L. Ravasi, +6 authors W. Eckelman
  • Published 2006
  • Medicine
  • European Journal of Nuclear Medicine and Molecular Imaging
  • PurposeTo determine whether brain and plasma equilibrium of a proposed PET tracer for 5-HT1A, [18F]FPWAY, can be achieved in a sufficiently short time for practical use of the brain to plasma equilibrium distribution ratio (DR) to monitor receptor availability with and without isoflurane anesthesia.MethodsAwake (n=4) and isoflurane-anesthetized (n=4) rats were administered a continuous 60 min intravenous infusion of [18F]FPWAY with timed arterial blood sampling. Brains of the isoflurane… CONTINUE READING
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