Distribution of the 3-hydroxyl-3-methylglutaryl coenzyme A reductase gene and isoprenoid production in marine-derived Actinobacteria.

@article{Khan2010DistributionOT,
  title={Distribution of the 3-hydroxyl-3-methylglutaryl coenzyme A reductase gene and isoprenoid production in marine-derived Actinobacteria.},
  author={Shams Tabrez Khan and Miho Izumikawa and Keiichiro Motohashi and Akira Mukai and Motoki Takagi and Kazuo Shin-Ya},
  journal={FEMS microbiology letters},
  year={2010},
  volume={304 1},
  pages={89-96}
}
During the course of our screening program to isolate isoprenoids from marine Actinobacteria, 523 actinobacterial strains were isolated from 18 marine sponges, a tunicate, and two marine sediments. These strains belonged to 21 different genera, but most were members of Streptomyces, Nocardia, Rhodococcus, and Micromonospora. Some Actinobacteria have been reported to use the mevalonate pathway for the production of isoprenoids as secondary metabolites. Therefore, we investigated whether these… CONTINUE READING

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