Distribution of surface glycoproteins on influenza A virus determined by electron cryotomography

@inproceedings{Wasilewski2012DistributionOS,
  title={Distribution of surface glycoproteins on influenza A virus determined by electron cryotomography},
  author={Sebastian Wasilewski and Lesley J. Calder and Tim Grant and Peter David Blanck Robert Rosenthal},
  booktitle={Vaccine},
  year={2012}
}
We use electron cryotomography to reconstruct virions of two influenza A H3N2 virus strains. The maps reveal the structure of the viral envelope containing hemagglutinin (HA) and neuraminidase (NA) glycoproteins and the virus interior containing a matrix layer and an assembly of ribonucleoprotein particles (RNPs) that package the genome. We build a structural model for the viral surface by locating copies of the X-ray structure of the HA ectodomain into density peaks on the virus surface. We… CONTINUE READING
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