Distribution of prothrombin carbohydrate units upon thrombin activation.

  title={Distribution of prothrombin carbohydrate units upon thrombin activation.},
  author={Billy G. Hudson and Charles M. Heldebrant and Kenneth G. Mann},
  journal={Thrombosis research},
  volume={6 3},
Abstract The number of heteropolysaccharide units of prothrombin has been reinvestigated and their distribution upon activation has been determined. The results of this study suggest that prothrombin contains three heteropolysaccharide units, and that upon activation two units are present in the intermediate 3 portion of the molecule and one unit is present in the intermediate 1 portion. Subsequent activation of intermediate 1 yields intermediate 4, which is devoid of carbohydrate and… CONTINUE READING

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