Distribution of prepro‐nociceptin/ orphanin FQ mRNA and its receptor mRNA in developing and adult mouse central nervous systems

@inproceedings{Ikeda1998DistributionOP,
  title={Distribution of prepro‐nociceptin/ orphanin FQ mRNA and its receptor mRNA in developing and adult mouse central nervous systems},
  author={Kazutaka Ikeda and Masanori Watanabe and Tomio Ichikawa and Toru Kobayashi and Ryoji Yano and Toshiro Kumanishi},
  year={1998}
}
Nociceptin/orphanin FQ (N/OFQ) and its receptor share similarities to opioids and their receptors in terms of the molecular structure and signaling pathway, but the two systems exhibit different actions in vivo. To understand the mechanism of N/OFQ-system actions, we examined, by in situ hybridization analysis, the distribution of preproN/OFQ and N/OFQ receptor mRNAs in the developing and adult mouse central nervous systems (CNS). In most neural regions, preproN/OFQ mRNA was mainly expressed in… CONTINUE READING

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