Distribution of platinum in blood and perilymph in relation to cisplatin induced ototoxicity in the guinea pig.

Abstract

Cisplatin, a platinum-based chemotherapeutic drug, has severe dose-limiting side effects which include ototoxicity. In this study, we investigate the ototoxic effects of cisplatin in relation to the concentration of platinum in whole blood, plasma and perilymph. Guinea pigs were equipped with a permanent round window electrode for electrocochleography and… (More)
DOI: 10.1016/j.heares.2008.10.001

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