Distribution of pentamidine in patients with AIDS.

  title={Distribution of pentamidine in patients with AIDS.},
  author={H J Donnelly and Edward M Bernard and H Rothkotter and Jonathan W M Gold and Derrek Armstrong},
  journal={The Journal of infectious diseases},
  volume={157 5},
We used a bioassay to measure pentamidine concentrations in autopsy specimens from 22 patients with AIDS. Patients received pentamidine isethionate (approximately 4 mg/kg per day) parenterally for Pneumocystis carinii pneumonia; one received monthly prophylaxis. We found that lung levels of 30 micrograms/g were achieved only after the fifth dose; tissue accumulation was usually greater in the liver, kidney, adrenal, and spleen than in the lung; detectable levels were present in some tissues as… CONTINUE READING
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