Distribution of organic anion transporters NaDC3 and OAT1-3 along the human nephron.

  title={Distribution of organic anion transporters NaDC3 and OAT1-3 along the human nephron.},
  author={Davorka Breljak and Marija Ljubojevi{\'c} and Yohannes Hagos and Vedran Micek and Daniela Balen Eror and Ivana Vrhovac Maduni{\'c} and Hrvoje Brzica and Dean Karaica and Nikola Radovi{\'c} and Ognjen Kraus and Naohiko Anzai and Hermann Koepsell and Gerhard Burckhardt and Birgitta Christina Burckhardt and Ivan Sabolic},
  journal={American journal of physiology. Renal physiology},
  volume={311 1},
The initial step in renal secretion of organic anions (OAs) is mediated by transporters in the basolateral membrane (BLM). Contributors to this process are primary active Na(+)-K(+)-ATPase (EC, secondary active Na(+)-dicarboxylate cotransporter 3 (NaDC3/SLC13A3), and tertiary active OA transporters (OATs) OAT1/SLC22A6, OAT2/SLC22A7, and OAT3/SLC22A8. In human kidneys, we analyzed the localization of these transporters by immunochemical methods in tissue cryosections and isolated… CONTINUE READING
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