Distribution of nociceptin/orphanin FQ in adult human brain

  title={Distribution of nociceptin/orphanin FQ in adult human brain},
  author={Jassir Witta and Mikl{\'o}s Palkovits and John Rosenberger and Brian M. Cox},
  journal={Brain Research},
Nociceptin/orphanin FQ (N/OFQ), the endogenous agonist for the opioid receptor-like receptor 1 (ORL1), shows significant similarities to dynorphin A in structure and distribution in rat central nervous system. The distribution of N/OFQ in human brain has not been studied. We measured the concentrations of N/OFQ in 47 microdissected areas of the central nervous system of adult human brain using radioimmunoassay (RIA). Significant heterogeneity was found in the levels of N/OFQ concentration in… CONTINUE READING


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