Distribution of morphine 6-glucuronide and morphine across the blood-brain barrier in awake, freely moving rats investigated by in vivo microdialysis sampling.


Microdialysis was used to sample morphine 6-glucuronide (M6G) and morphine in striatal extracellular fluid after systemic administration in awake, freely moving rats. Morphine or M6G (25-67 mumol/kg) was given subcutaneously, and blood and striatal dialysate were sampled repeatedly during 120 min. Blood samples were obtained by indwelling catheters in the… (More)