Distribution of mitochondrial nucleoids upon mitochondrial network fragmentation and network reintegration in HEPG2 cells.

@article{Tauber2013DistributionOM,
  title={Distribution of mitochondrial nucleoids upon mitochondrial network fragmentation and network reintegration in HEPG2 cells.},
  author={Jan Tauber and Andrea Dlaskov{\'a} and Jitka {\vS}antorov{\'a} and Katar{\'i}na Smolkov{\'a} and Luk{\'a}{\vs} Al{\'a}n and Tom{\'a}{\vs} {\vS}pa{\vc}ek and Lydie Plecit{\'a}-Hlavat{\'a} and Martin Jabůrek and Petr Jezek},
  journal={The international journal of biochemistry & cell biology},
  year={2013},
  volume={45 3},
  pages={
          593-603
        }
}
Mitochondrial DNA (mtDNA) is organized in nucleoids in complex with accessory proteins, proteins of mtDNA replication and gene expression machinery. A robust mtDNA genome is represented by hundreds to thousands of nucleoids in cell mitochondrion. Detailed information is lacking about the dynamics of nucleoid distribution within the mitochondrial network upon physiological and pathological events. Therefore, we used confocal microscopy to study mitochondrial nucleoid redistribution upon… CONTINUE READING
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