Distribution of methotrexate in human blood in vitro: independence of temperature, pH and drug concentration.

Abstract

Distribution of methotrexate (MTX) in blood samples from a single donor as a function of incubation time, temperature, pH and drug concentration was investigated. Equilibrium, as expressed by the cell/plasma (C/P) partition ratio, was reached rapidly and was constant for 5 to 30 min following incubation. The C/P ratio was unaffected by temperature… (More)

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@article{Slrdal1987DistributionOM, title={Distribution of methotrexate in human blood in vitro: independence of temperature, pH and drug concentration.}, author={L. H. Sl\ordal and Jarle Aarbakke}, journal={International journal of clinical pharmacology, therapy, and toxicology}, year={1987}, volume={25 8}, pages={417-20} }