Distribution of membrane progesterone receptor alpha in the male mouse and rat brain and its regulation after traumatic brain injury.

@article{Meffre2013DistributionOM,
  title={Distribution of membrane progesterone receptor alpha in the male mouse and rat brain and its regulation after traumatic brain injury.},
  author={Delphine Meffre and Florencia Labombarda and Brigitte Delespierre and Anne Chastre and Alejandro Federico De Nicola and Donald G. Stein and Michael Schumacher and Rachida Guennoun},
  journal={Neuroscience},
  year={2013},
  volume={231},
  pages={111-24}
}
Progesterone has been shown to exert pleiotropic actions in the brain of both male and females. In particular, after traumatic brain injury (TBI), progesterone has important neuroprotective effects. In addition to intracellular progesterone receptors, membrane receptors of the hormone such as membrane progesterone receptor (mPR) may also be involved in neuroprotection. Three mPR subtypes (mPRα, mPRβ, and mPRγ) have been described and mPRα is best characterized pharmacologically. In the present… CONTINUE READING

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