Distribution of meiotic recombination along nondisjunction chromosomes 21 in Down syndrome determined using cytogenetics and RFLP haplotyping

@article{Meijer1989DistributionOM,
  title={Distribution of meiotic recombination along nondisjunction chromosomes 21 in Down syndrome determined using cytogenetics and RFLP haplotyping},
  author={Henk Meijer and Guus J. H. Hamers and Roselie J. E. Jongbloed and Gerrie P. M. Vaes-Peeters and Ren{\'e} R. W. J. van der Hulst and Joep P. M. Geraedts},
  journal={Human Genetics},
  year={1989},
  volume={83},
  pages={280-286}
}
Ten families (Down syndrome children and their parents) showing evidence of meiotic recombination between intraparental chromosomes transmitted after nondisjunction were studied. Cytogenetic polymorphisms and a cassette of RFLP markers distributed along chromosome 21 were used to analyze these families to localize the regions of meiotic recombination. Results indicated that only one crossover occurred per meiotic division and that nine of ten nondisjunctions appeared to be of maternal origin… CONTINUE READING

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