Distribution of liposomes into brain and rat brain tumor models by convection-enhanced delivery monitored with magnetic resonance imaging.

@article{Saito2004DistributionOL,
  title={Distribution of liposomes into brain and rat brain tumor models by convection-enhanced delivery monitored with magnetic resonance imaging.},
  author={Ryuta Saito and John R. Bringas and Tracy R Mcknight and M. Wendland and Christoph Mamot and Daryl C. Drummond and Dmitri B. Kirpotin and John Jae Won Park and Mitchel S. Berger and Krys S. Bankiewicz},
  journal={Cancer research},
  year={2004},
  volume={64 7},
  pages={2572-9}
}
Although liposomes have been used as a vehicle for delivery of therapeutic agents in oncology, their efficacy in targeting brain tumors has been limited due to poor penetration through the blood-brain barrier. Because convection-enhanced delivery (CED) of liposomes may improve the therapeutic index for targeting brain tumors, we conducted a three-stage study: stage 1 established the feasibility of using in vivo magnetic resonance imaging (MRI) to confirm adequate liposomal distribution within… CONTINUE READING

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