Distribution of integrin subunits in human diabetic kidneys.

  title={Distribution of integrin subunits in human diabetic kidneys.},
  author={Dong-kyu Jin and Alfred J. Fish and Elizabeth A. Wayner and Michael G. Mauer and S. G. Rameshaiah Setty and Effie C. Tsilibary and Y. Kim},
  journal={Journal of the American Society of Nephrology : JASN},
  volume={7 12},
Integrins are cell-surface protein receptors that participate in cell adhesion to multiple extracellular matrix ligands, and consist of alpha and beta chain heterodimers. This study examined altered integrin distribution in diabetic nephropathy by investigating 12 human diabetic kidney biopsies, which were compared with normal human kidney. Diabetic nephropathy is characterized by mesangial expansion and progressive thickening of the glomerular basement membrane. Based on morphometric studies… CONTINUE READING