Distribution of human immunodeficiency virus type 1 protease and reverse transcriptase mutation patterns in 4,183 persons undergoing genotypic resistance testing.

Abstract

In a sample of 6,156 sequences from 4,183 persons, the top 30 patterns of protease inhibitor, nucleoside reverse transcriptase (RT) inhibitor, and nonnucleoside RT inhibitor mutations accounted for 55, 46, and 66%, respectively, of sequences with drug resistance mutations. Characterization of the phenotypic and clinical significance of these common patterns may lead to improved treatment recommendations for a large proportion of patients for whom antiretroviral therapy is failing.

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@article{Rhee2004DistributionOH, title={Distribution of human immunodeficiency virus type 1 protease and reverse transcriptase mutation patterns in 4,183 persons undergoing genotypic resistance testing.}, author={Soo-Yon Rhee and Tommy F. Liu and Jaideep Ravela and Matthew J. Gonzales and Robert W. Shafer}, journal={Antimicrobial agents and chemotherapy}, year={2004}, volume={48 8}, pages={3122-6} }