Distribution of hepatitis C virus RNA in the liver and its relation to histopathological changes.

@article{Kojima1996DistributionOH,
  title={Distribution of hepatitis C virus RNA in the liver and its relation to histopathological changes.},
  author={Somei Kojima and Yasuhito Tanaka and Nobuyuki Enomoto and Fumiaki Marumo and Chifumi Sato},
  journal={Liver},
  year={1996},
  volume={16 1},
  pages={55-60}
}
To investigate a cellular mode of HCV-infection in the liver and its pathological implications in relation to histopathological changes or clinical data, we studied the distribution of HCV-RNA in the livers of 21 patients with HCV-related chronic liver disease (chronic active hepatitis, 14 cases; cirrhosis, 7 cases) using the in situ hybridization technique. In situ hybridization was performed on 4% paraformaldehyde-fixed frozen sections with digoxigenin-labeled DNA probe deduced from the core… CONTINUE READING