Distribution of glucocorticoid and mineralocorticoid receptor messenger RNA expression in human postmortem hippocampus.

@article{Seckl1991DistributionOG,
  title={Distribution of glucocorticoid and mineralocorticoid receptor messenger RNA expression in human postmortem hippocampus.},
  author={Jonathan R Seckl and Kenneth L. Dickson and Catherine Yates and George Fink},
  journal={Brain research},
  year={1991},
  volume={561 2},
  pages={332-7}
}
Corticosteroids bind to hippocampal glucocorticoid (GR) and mineralocorticoid (MR) receptors, thereby affecting behaviour and neurochemical transmission. Rat hippocampus has high levels of both receptors and their messenger RNAs (mRNA), but there is little information on receptors in human brain. We used in situ hybridization to determine the distribution of GR and MR mRNA expression in human hippocampus. Frozen sections of human postmortem hippocampus (5 patients, 58-88 years old, without… CONTINUE READING

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