Distribution of fragile X mental retardation protein in the human auditory brainstem.

  title={Distribution of fragile X mental retardation protein in the human auditory brainstem.},
  author={Karisa Beebe and Yu Winston Wang and Randy Joseph Kulesza},
Fragile X mental retardation protein (FMRP) binds select mRNAs, functions in intracellular transport of these mRNAs and represses their translation. FMRP is highly expressed in neurons and lack of FMRP has been shown to result in dendritic dysmorphology and altered synaptic function. FMRP is known to interact with mRNAs for the Kv3.1b potassium channel which is required for neurons to fire action potentials at high rates with remarkable temporal precision. Auditory brainstem neurons are known… CONTINUE READING
Related Discussions
This paper has been referenced on Twitter 1 time. VIEW TWEETS


Publications citing this paper.


Publications referenced by this paper.
Showing 1-10 of 85 references

Region-specific alterations in brain development in one- to three-year-old boys with fragile X syndrome.

Proceedings of the National Academy of Sciences of the United States of America • 2010
View 4 Excerpts
Highly Influenced

neurotransmitter release and synaptic information transmission by modulating action potential duration via BK channels

D Devys, Y Lutz, N Rouyer, JP Bellocq, JL Mandel

FMRP regulates

PY Deng, Z Rotman, +5 authors VA Klyachko
View 2 Excerpts

Similar Papers

Loading similar papers…