Distribution of fragile X mental retardation protein in the human auditory brainstem.

@article{Beebe2014DistributionOF,
  title={Distribution of fragile X mental retardation protein in the human auditory brainstem.},
  author={Karisa Beebe and Yu Winston Wang and Randy Joseph Kulesza},
  journal={Neuroscience},
  year={2014},
  volume={273},
  pages={79-91}
}
Fragile X mental retardation protein (FMRP) binds select mRNAs, functions in intracellular transport of these mRNAs and represses their translation. FMRP is highly expressed in neurons and lack of FMRP has been shown to result in dendritic dysmorphology and altered synaptic function. FMRP is known to interact with mRNAs for the Kv3.1b potassium channel which is required for neurons to fire action potentials at high rates with remarkable temporal precision. Auditory brainstem neurons are known… CONTINUE READING
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