Distribution of fitness effects among beneficial mutations before selection in experimental populations of bacteria

@article{Kassen2006DistributionOF,
  title={Distribution of fitness effects among beneficial mutations before selection in experimental populations of bacteria},
  author={R. Kassen and T. Bataillon},
  journal={Nature Genetics},
  year={2006},
  volume={38},
  pages={484-488}
}
  • R. Kassen, T. Bataillon
  • Published 2006
  • Medicine, Biology
  • Nature Genetics
  • The extent to which a population diverges from its ancestor through adaptive evolution depends on variation supplied by novel beneficial mutations. Extending earlier work, recent theory makes two predictions that seem to be robust to biological details: the distribution of fitness effects among beneficial mutations before selection should be (i) exponential and (ii) invariant, meaning it is always exponential regardless of the fitness rank of the wild-type allele. Here we test these predictions… CONTINUE READING

    Figures, Tables, and Topics from this paper.

    Explore Further: Topics Discussed in This Paper

    The distribution of fitness effects of new mutations
    • 1,014
    • PDF
    The Distribution of Fitness Effects of Beneficial Mutations in Pseudomonas aeruginosa
    • 118
    Beneficial Fitness Effects Are Not Exponential for Two Viruses
    • 102
    • Highly Influenced
    • PDF
    Cost of Adaptation and Fitness Effects of Beneficial Mutations in Pseudomonas fluorescens
    • 70
    • PDF
    Global epistasis makes adaptation predictable despite sequence-level stochasticity
    • 220
    • Highly Influenced
    • PDF
    The Distribution of Beneficial Mutant Effects Under Strong Selection
    • 53
    • PDF
    The Distribution of Beneficial and Fixed Mutation Fitness Effects Close to an Optimum
    • 86
    • PDF

    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 23 REFERENCES
    Fitness effects of advantageous mutations in evolving Escherichia coli populations.
    • 249
    • Highly Influential
    • PDF
    The distribution of fitness effects among beneficial mutations.
    • 264
    • PDF