Distribution of extracellular tracers in perivascular spaces of the rat brain

@article{Ichimura1991DistributionOE,
  title={Distribution of extracellular tracers in perivascular spaces of the rat brain},
  author={Takao Ichimura and Paul A. Fraser and Helen F. Cserr},
  journal={Brain Research},
  year={1991},
  volume={545},
  pages={103-113}
}
Large molecular weight tracers (india ink or albumin labeled with colloidal gold, Evans blue or rhodamine) were micro-injected into the perivascular space of an artery or vein on the brain surface, or within the cerebral cortex or the subarachnoid space of anesthetized rats. The subsequent distribution was followed both under intravital microscopy, in order to outline the pathways and direction of tracer movement, and in histological section, in order to describe the pathways of flow at the… 
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Trafficking of Glucose, Lactate, and Amyloid-β from the Inferior Colliculus through Perivascular Routes
  • K. Ball, N. Cruz, R. Mrak, G. Dienel
  • Medicine
    Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism
  • 2010
TLDR
This study evaluated release of metabolites and proteins through perivascular fluid flow, a pathway that carries solutes from brain to peripheral lymphatic drainage sites, and found convergence of ‘watershed’ drainage to common pathways may facilitate periv vascular amyloid plaque formation and pathway obstruction in Alzheimer's disease.
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