Distribution of extracellular matrix components in nuchal skin from fetuses carrying trisomy 18 and trisomy 21

@article{BrandSaberi1994DistributionOE,
  title={Distribution of extracellular matrix components in nuchal skin from fetuses carrying trisomy 18 and trisomy 21},
  author={Beate E M Brand-Saberi and Hans Henning Epperlein and Georgios E Romanos and B. G. Christ},
  journal={Cell and Tissue Research},
  year={1994},
  volume={277},
  pages={465-475}
}
We have investigated histologically the elevations of the skin in dorsal and lateral neck (nuchal) regions of human fetuses carrying karyotypes of trisomy 18 (Edwards' syndrome) and trisomy 21 (Down's syndrome). Cavities filled with interstitial fluid were found in the dermis, epidermal basement membrane and occasionally in the epidermis of trisomy-18 fetuses, but were not delineated by an epithelium or basement membrane as judged by the absence of immunostaining for laminin, collagen IV and… CONTINUE READING
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