Distribution of drugs over whole blood: I. The transport function of whole blood for valproate.

@article{Driessen1989DistributionOD,
  title={Distribution of drugs over whole blood: I. The transport function of whole blood for valproate.},
  author={O. M. J. Driessen and L Treuren and Jan Willem Meijer},
  journal={Therapeutic drug monitoring},
  year={1989},
  volume={11 4},
  pages={384-9}
}
A method is presented for the determination of valproate (VPA) in approximately 40 microliters erythrocyte concentrations. Valproate partition between plasma proteins, ultrafiltrate, and erythrocytes at various concentrations was studied in vitro and in vivo. Partition ratios depended on VPA concentration in whole blood and the ratio of erythrocytes/ultrafiltrate, which increased with rising concentrations in the ultrafiltrate fraction. Shifts in ratios were studied by expanding the… CONTINUE READING