Distribution of diazepam and nordiazepam between plasma and whole blood and the influence of hematocrit.

@article{Jones2004DistributionOD,
  title={Distribution of diazepam and nordiazepam between plasma and whole blood and the influence of hematocrit.},
  author={Alan Wayne Jones and Helena Hultin Larsson},
  journal={Therapeutic drug monitoring},
  year={2004},
  volume={26 4},
  pages={380-5}
}
The binding of drugs to plasma proteins is important to consider when concentrations in whole blood (eg, in forensic toxicology) are compared with therapeutic and toxic concentrations based on the analysis of plasma or serum. The plasma to whole blood distribution of diazepam (D) and its major metabolite nordiazepam (ND) was investigated under in vitro and ex vivo conditions. Studies in vitro were done by spiking whole blood with D and ND to give concentrations ranging from 0.1 to 1.0 microg/g… CONTINUE READING

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