Distribution of corticotropin-releasing factor neurons in the mouse brain: a study using corticotropin-releasing factor-modified yellow fluorescent protein knock-in mouse

@article{Kono2016DistributionOC,
  title={Distribution of corticotropin-releasing factor neurons in the mouse brain: a study using corticotropin-releasing factor-modified yellow fluorescent protein knock-in mouse},
  author={Junko Kono and Kohtarou Konno and Ashraf Hossain Talukder and Toshimitsu Fuse and Manabu Abe and Katsuya Uchida and Shuhei Horio and Kenji Sakimura and Masahiko Watanabe and Keiichi Itoi},
  journal={Brain Structure and Function},
  year={2016},
  volume={222},
  pages={1705-1732}
}
We examined the morphological features of corticotropin-releasing factor (CRF) neurons in a mouse line in which modified yellow fluorescent protein (Venus) was expressed under the CRF promoter. We previously generated the CRF-Venus knock-in mouse, in which Venus is inserted into the CRF gene locus by homologous recombination. In the present study, the neomycin phosphotransferase gene (Neo), driven by the pgk-1 promoter, was deleted from the CRF-Venus mouse genome, and a CRF-Venus∆Neo mouse was… CONTINUE READING

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