Distribution of cell populations with DNA aneuploidy and p53 protein expression in ulcerative colitis.

@article{Klump1997DistributionOC,
  title={Distribution of cell populations with DNA aneuploidy and p53 protein expression in ulcerative colitis.},
  author={Bodo Klump and Karlheinz Holzmann and Adam Kuehn and Franz Borchard and Mario Sarbia and Michael Gregor and Rainer Porschen},
  journal={European journal of gastroenterology & hepatology},
  year={1997},
  volume={9 8},
  pages={789-94}
}
OBJECTIVE Patients with ulcerative colitis are at an increased risk for developing colorectal neoplasms. p53 mutations and the occurrence of DNA aneuploidies are common events in the development of sporadic colorectal neoplasias. This study tried to determine the frequency of these events during the development of colitis-associated colorectal neoplasms. DESIGN/METHODS Four colectomy specimens with a total of 124 biopsies were investigated. DNA content was measured by flow cytometry and p53… CONTINUE READING
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