Distribution of catechol-O-methyltransferase expression in human central nervous system.

@article{Hong1998DistributionOC,
  title={Distribution of catechol-O-methyltransferase expression in human central nervous system.},
  author={J Hong and H Shu-Leong and X Tao and Y Lap-Ping},
  journal={Neuroreport},
  year={1998},
  volume={9 12},
  pages={2861-4}
}
Catechol-O-methyltransferase (COMT, EC 2.1.1.6) is a ubiquitous enzyme crucial to catechol metabolism. Two isoforms exist in the human central nervous system (CNS) and they are encoded by two transcripts (1.3 and 1.5 kb) in most human tissues. Using two alpha-32P-labeled probes, we found only the 1.5 kb transcript in all 16 regions of the human CNS using commercially available Northern blots. Spinal cord had the highest and amygdala had the lowest levels of expression. The other CNS regions… CONTINUE READING

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