Distribution of bombesin binding sites in the rat gastrointestinal tract.

  title={Distribution of bombesin binding sites in the rat gastrointestinal tract.},
  author={Timothy H. Moran and Terry W. Moody and A M Hostetler and P. H. Robinson and Michael S Goldrich and Paul R. McHugh},
  volume={9 3},
In an attempt to identify potential target sites for the satiety action of bombesin (BN), the distribution and pharmacological specificity of bombesin binding sites were examined in the rat gastrointestinal tract by in vitro autoradiography utilizing (125I-Tyr4) bombesin. Specific BN binding was localized to the circular muscle level of the gastric fundus and antrum, submucosal layer of the small intestine and longitudinal and circular muscle and submucosal layers of the colon. Pharmacological… CONTINUE READING


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