Distribution of betulinic acid in plant kingdom

@article{Pai2014DistributionOB,
  title={Distribution of betulinic acid in plant kingdom},
  author={Sandeep Ramchandra Pai and Rajesh K. Joshi},
  journal={Plant Science today},
  year={2014},
  volume={1},
  pages={103-107}
}
Betulinic acid (3s-hydroxy-lup-20(29)-en-28-oic acid) is a ubiquitous pentacyclic triterpenoid found in the plants. It is highly valued for its role in wide array of ailments viz. anti-HIV, anti-malarial, anti-cancerous, hepatoprotective, and many more. In lights of tremendous interest in recent years on chemistry and pharmacological properties of betulinic acid (BA), comprehensive data have been collected in this review to present its distribution in plant kingdom. 

Figures and Tables from this paper

Chemical Strategies towards the Synthesis of Betulinic Acid and Its More Potent Antiprotozoal Analogues
TLDR
BA is a molecule of great interest as a starting material for the synthesis of novel antiprotozoal agents, and some interesting antitrypanosomal derivatives were prepared by amide formation at the C-28 carboxylic group of the lupane skeleton.
Variations in Pentacyclic Triterpenoids in Different Parts of Four Ocimum Species Using Reverse Phase-High Performance Liquid Chromatography
  • S. Pai, R. Joshi
  • Chemistry
    Proceedings of the National Academy of Sciences, India Section B: Biological Sciences
  • 2015
Betulinic acid (BA), oleanolic acid (OA) and ursolic acid (UA) are the important pentacyclic triterpenoid compounds known for their anti-inflammatory, trypanocidal, antirheumatic, antiviral,
Biotechnological production of betulinic acid and derivatives and their applications
TLDR
This review highlighted recent advances in biotechnological production of BA-related compounds and attempted to provide future perspectives on potential strategies for further optimizing biosynthesis of BA and other triterpenoids in microbial hosts.
Chemical diversity and antiviral potential in the pantropical Diospyros genus.
TLDR
A screening using a dengue replicon virus-cell-based assay was performed on ethyl acetate extracts from different parts of 1500 plants, and showed that chemical similarity is not related to plant species or organ.
hytochemistry and antimicrobial activity of Campomanesia damantium tone
Campomanesia adamantium (Cambess.) O. Berg., Myrtaceae, is a plant popularly used for its antiinflammatory, anti-diarrhoeal and urinary antiseptic activities. The aims of this study were to obtain
Phytochemistry and antimicrobial activity of Campomanesia adamantium
Abstract Campomanesia adamantium (Cambess.) O. Berg., Myrtaceae, is a plant popularly used for its anti-inflammatory, anti-diarrhoeal and urinary antiseptic activities. The aims of this study were to
Autoxidation Products of Betulonaldehyde.
TLDR
Three major degradation products resulted from the exposure of betulonaldehyde to air in solution at room temperature were identified as betulonic acid and C-17 hydroperoxide epimers 3 (β-OOH) and 4 (α-OOOH).
Betulinic Acid and Brosimine B Hybrid Derivatives as Potential Agents against Female Cancers.
TLDR
It is shown that the combination of two complex structures generated the development of hybrids with differing inhibitory profiles and apoptotic modes of action, thus representing potential alternatives in female cancer treatment.
Comparative HPTLC analysis of stem and leaf of Achyranthes coynei with Achyranthes aspera
TLDR
HPTLC analysis in absence of external standards proved to be an informative tool for evaluating differences between these species and their parts.
Optimized Densitometric Analysis for Determination of Triterpenoid Isomers in Vitex negundo L. Leaf
Triterpenoid isomers oleanolic acid (OA) and betulinic acid (BA) were densitometrically separated and quantified using an optimized high performance thin layer chromatography analysis in Vitex
...
1
2
...

References

SHOWING 1-10 OF 46 REFERENCES
Betulinic acid and its derivatives: a review on their biological properties.
TLDR
A survey of the literature dealing with betulinic acid related biological properties that has appeared from the 1990's to the beginning of 2003 is reported.
Two novel compounds from Paeonia suffructicosa.
TLDR
A new hexacyclic triterpenoid, mudanpinoic acid A, and a new gallic acid glycoside, mudanoside B, along with nine known compounds were isolated from the dried root cortex of Paeonia suffruticosa.
Terpenoids of Syzygium formosanum.
TLDR
A new natural product, 4-epifriedelin, and 12 known terpenoids have been isolated from the leaves of Syzygium formosanum, reported for the first time.
Identification of three triterpenoids in almond hulls.
TLDR
These studies demonstrate that almond hulls are a rich source of these triterpenoids, which have reported anti-inflammatory, anti-HIV, and anti-cancer activities.
Investigations on the steroidal anti-inflammatory activity of triterpenoids from Diospyros leucomelas.
Three triterpenes were isolated from Diospyros leucomelas and identified as betulin, betulinic acid, and ursolic acid. They showed anti-inflammatory activity in the carrageenan and serotonin paw
A New Norlupene from the Leaves of Melaleuca leucadendron
  • Lee
  • Biology, Medicine
    Journal of natural products
  • 1998
A new lupane-type nortriterpene and 13 known compounds were isolated from the leaves of Melaleuca leucadendron L. Based on chemical and spectral methods, the structure of the new compound was
Chemical constituents from Tabernaemontana catharinensis root bark: a brief NMR review of indole alkaloids and in vitro cytotoxicity
TLDR
Compounds ibogamine, 3-oxo-coronaridine and 12-methoxy-4-methylvoachalotine demonstrated effective cytotoxicity towards SKBR-3 breast adenocarcinoma and C-8161 human melanoma tumor cell lines.
Triterpenes acids and saponins isolated from Licania arianeae Prance (Chrysobalanaceae)
TLDR
From the leaves and wood of Licania arianeae, ten known compounds were isolated and identified, including three oleanoic acids, five ursane acids, and two triterpenes saponin acids, which belong to pharmacological active triter penes acids.
Betulinic acid: isolation from Triphyophyllum peltatum and Ancistrocladus heyneanus, antimalarial activity, and crystal structure of the benzyl ester.
The known lupane-type triterpene betulinic acid (3) was isolated for the first time from Triphyophyllum peltatum and Ancistrocladus heyneanus. It was found to exhibit moderate to good in vitro
New 3-O-acyl betulinic acids from Strychnos vanprukii Craib.
TLDR
Three new betulinic acid derivatives and two known triterpenes were isolated from the leaves and twigs of Strychnos vanprukiiCraib showed moderate anti-HIV activity with IC50 values ranging from 3 to 7 microg/mL in an indicator cell line for HIV infectivity.
...
1
2
3
4
5
...