Distribution of aquaporin-4 water channel expression within rat kidney.

  title={Distribution of aquaporin-4 water channel expression within rat kidney.},
  author={James M Terris and Carolyn M A Ecelbarger and David Marples and Mark A. Knepper and S\oren Lyhne Nielsen},
  journal={The American journal of physiology},
  volume={269 6 Pt 2},
The aquaporins are a family of transmembrane proteins that function as molecular water channels. Recently, a mercurial-insensitive water channel [MIWC or aquaporin-4 (AQP4)] has been cloned, and its mRNA was found to be expressed strongly in kidney inner medulla and several nonrenal tissues. We prepared affinity-purified polyclonal antipeptide antibodies to AQP4 to define the regional distribution and cellular location of this water channel within the kidney. Immunoblotting of membrane… CONTINUE READING
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