Distribution of angiotensin-converting enzyme and angiotensin II-receptor binding sites in the rat ovary.

@article{Speth1988DistributionOA,
  title={Distribution of angiotensin-converting enzyme and angiotensin II-receptor binding sites in the rat ovary.},
  author={Robert C Speth and Ahsan Husain},
  journal={Biology of reproduction},
  year={1988},
  volume={38 3},
  pages={695-702}
}
Recent reports of the presence of components of the renin-angiotensin system (RAS) in the mammalian ovary suggest that angiotensin II (Ang II) may be elaborated by this structure. In this study, angiotensin-converting enzyme (ACE), a key enzyme in the synthesis of Ang II, was identified enzymatically and localized to the germinal epithelium surrounding corpora lutea, granulosa cells of some--but not all--follicles, and blood vessels of the rat ovary using a potent and specific radiolabeled ACE… CONTINUE READING