Corpus ID: 15510959

Distribution of angiotensin II receptors in rat and human adipocytes.

@article{Crandall1994DistributionOA,
  title={Distribution of angiotensin II receptors in rat and human adipocytes.},
  author={D. L. Crandall and H. Herzlinger and B. D. Saunders and D. Armellino and J. Kral},
  journal={Journal of lipid research},
  year={1994},
  volume={35 8},
  pages={
          1378-85
        }
}
Angiotensin II (AII) receptor binding assays were performed in rat adipocytes from three separate anatomic depots. Fat cells were isolated by collagenase digestion, and plasma membranes were prepared from the epididymal, mesenteric, and retroperitoneal fat depots of male Sprague-Dawley rats at 100 days of age. Binding of 125I-labeled [Sar1,Ile8]AII was rapid, saturable, and specific in membranes from all depots, identifying a receptor with a similar affinity of approximately 1 nM. Site… Expand
Characterization and Regulation of Angiotensin II Receptors in Rat Adipose Tissue
Characterization and regulation of angiotensin II (AII) receptor binding sites was performed in rat membrane preparations from nonadipose (liver, lung) and adipose (interscapular (ISBAT) andExpand
The role of angiotensin II and its receptors in regulation of adipose tissue metabolism and cellularity.
TLDR
Evidence of interaction between insulin and angiotensin II in regulation of adipose tissue metabolism and cellularity is found and Clarification of these interactions could lead to significant progress in pharmacological treatment of obesity and its comorbidity. Expand
Angiotensin II stimulates and atrial natriuretic peptide inhibits human visceral adipocyte growth
TLDR
A cell-culture model to study VAT growth showed stimulation by Ang II and inhibition by ANP at physiological concentrations and indicated that the effects of ANP were mediated by the guanylyl cyclase type A receptor. Expand
Androgen regulation and site specificity of angiotensinogen gene expression and secretion in rat adipocytes.
TLDR
Data, demonstrating both in vivo and in vitro androgen induction of ATG mRNA expression in rat adipocytes, add further weight to the hypothesis of a link between adipose tissue ATG production, androgens, and android obesity-related hypertension. Expand
Angiotensin II promotes leptin production in cultured human fat cells by an ERK1/2-dependent pathway.
TLDR
Ang II and its metabolites stimulated leptin production in human adipocytes through an extracellular-signal-regulated kinases 1 and 2-dependent pathway and includes the angiotensin II type 1 receptor subtype. Expand
The effects of angiotensin-II on lipolysis in humans.
  • R. Townsend
  • Chemistry, Medicine
  • Metabolism: clinical and experimental
  • 2001
TLDR
The general concept that the renin-angiotensin system in adipocytes serves more to regulate the regional blood flow to adipose tissue and the size and number of fat cells rather than participating directly in the regulation of energy substrate is supported. Expand
Deficiency of angiotensin type 1a receptors in adipocytes reduces differentiation and promotes hypertrophy of adipocytes in lean mice.
TLDR
It is demonstrated that AngII regulates adipocyte differentiation and morphology through the adipocyte AT1aR in lean mice. Expand
Angiotensin II: a hormone that affects lipid metabolism in adipose tissue
TLDR
Ang II directly inhibits abdominal subcutaneous adipocyte lipolysis in normal weight and obese subjects via the AT1 receptor. Expand
Angiotensin II increases lipogenesis in 3T3-L1 and human adipose cells.
TLDR
Ang II significantly increased triglyceride content and the activities of two key lipogenic enzymes in 3T3-L1 adipocytes, and that these effects were mediated through the type-2 Ang II receptor, indicating that Ang II may be involved in control of adiposity through regulation of lipid synthesis and storage in adipocytes. Expand
Rat epididymal fat tissue express all components of the renin-angiotensin system.
TLDR
Evidence is provided for the presence of the active renin-angiotensin system in rat adipose tissue and the main source of renin activity was found in adipocytes and some minor activity in the stromal-vascular fraction. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 40 REFERENCES
Identification and characterization of angiotensin II receptors in rat epididymal adipocyte membranes.
TLDR
These studies have successfully identified and characterized a high-affinity membrane receptor for AII in fat cells, further establishing adipose tissue as a peripheral site containing regulatory components of the local renin-angiotensin system. Expand
Distribution of angiotensin II receptor subtypes in rat brain nuclei
TLDR
It is found that approximately 25% of the ANG II receptors in hypothalamus did not bind DuP 753 even at 0.1 mM, which indicates that these sites which bind CGP 42112A, ANG II and sarilesin may represent a third ANG II receptor subtype. Expand
Characterization and development of angiotensin II receptor subtypes (AT1 and AT2) in rat brain.
TLDR
Their differential localization and development suggest different functions for the specific angiotensin II receptor sub types, which may be involved in control and learning of motor activity, sensory areas, and selected limbic system structures. Expand
Identification of two subtypes in the rat type I angiotensin II receptor
A rat adrenal cDNA library was screened by colony hybridization using a rat cDNA fragment of type I angiotensin II receptor (ATIA) previously isolated from the kidney. Two cDNA clones wereExpand
Tissue-specific nutritional regulation of angiotensinogen in adipose tissue.
TLDR
It is proposed that adipocyte angiotensinogen could play a previously unrecognized role in regulating adipose tissue blood supply and thereby fatty acid efflux from fat in a tissue-specific manner. Expand
Site differences in insulin receptor binding and insulin action in subcutaneous fat of obese females.
TLDR
Major regional differences in insulin binding and insulin action were found in sc fat depots in obese women, probably responsible for the enhanced insulin-induced glucose utilization in femoral fat. Expand
Heterogeneous distribution of beta and alpha‐2 adrenoceptor binding sites in human fat cells from various fat deposits: functional consequences
TLDR
The differences in the lipolytic responses to epinephrine in adipocytes from different sites are linked to a variablealpha‐2 inhibiting effect (and alpha‐2 site number) rather than to a modified beta driven increase in lipolysis initiated by the physiological amine. Expand
Transforming growth factor alpha and atrial natriuretic peptide in white adipose tissue depots in rats
TLDR
Data show significant concentrations of peptides with effects on growth in subfractions of adipose tissue and demonstrate regional differences in concentrations between fat depots. Expand
Novel sites of expression of functional angiotensin II receptors in the late gestation fetus.
TLDR
The abundance, timing of expression, and unique localization of functional AII receptors in the fetus suggest a role for AII in fetal development. Expand
Angiotensin-II receptor subtypes and coupling to signaling systems in cultured fetal fibroblasts.
TLDR
The presence of both AII receptor subtypes in fetal fibroblasts, but only the type 1 receptors are coupled to a known intracellular signalling system is demonstrated, suggesting that receptor synthesis is regulated at the posttranscriptional level. Expand
...
1
2
3
4
...