Distribution of angiotensin II receptor subtypes in rat brain nuclei

@article{Obermller1991DistributionOA,
  title={Distribution of angiotensin II receptor subtypes in rat brain nuclei},
  author={Nicholas Oberm{\"u}ller and Thomas Unger and Juraj Culman and Peter Gohlke and Marc de Gasparo and Serge Pierre Bottari},
  journal={Neuroscience Letters},
  year={1991},
  volume={132},
  pages={11-15}
}
Angiotensin II (ANG II) receptor subtypes in rat brain were characterized and quantified by competitive radioligand binding using [125I]Sar1 Ile8 angiotensin II ([125I]sarilesin) as a tracer and ANG II, sarilesin and the subtype selective ligands DuP 753 (AT1) and CGP 42112A (AT2) as competitors. The distribution of AT1 and AT2 receptors was determined in midbrain, brainstem, hypothalamus as well as in individual hypothalamic and periventricular nuclei. Whereas in midbrain and brainstem the AT1… CONTINUE READING

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