Distribution of alpha interferon in serum and cerebrospinal fluid after systemic administration.


After intravenous infusion of recombinant leukocyte interferon (rIFN-alpha A) to four subjects with an indwelling reservoir, serial serum and cerebrospinal fluid samples were taken over 48 hr and were analyzed for interferon by an enzyme immunoassay method (ELISA). On separate occasions, 18 and 50 X 10(6) of rIFN-alpha A were infused over 10 min. Maximum… (More)


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