Distribution of alpha 1C-adrenergic receptor mRNA in adult rat tissues by RNase protection assay and comparison with alpha 1B and alpha 1D.

@article{Rokosh1994DistributionOA,
  title={Distribution of alpha 1C-adrenergic receptor mRNA in adult rat tissues by RNase protection assay and comparison with alpha 1B and alpha 1D.},
  author={D. Gregg Rokosh and Beth Nordstrom Bailey and Andrew Francis Stewart and Larry R. Karns and Carlin S. Long and Paul C. Simpson},
  journal={Biochemical and biophysical research communications},
  year={1994},
  volume={200 3},
  pages={1177-84}
}
Two alpha 1-adrenergic receptor (AR) subtypes have been defined by pharmacological studies in rat tissues, the alpha 1A and the alpha 1B, whereas three alpha 1-ARs have been cloned, alpha 1B, alpha 1C, and alpha 1D. It has been reported that alpha 1C mRNA is absent in all rat tissues, making uncertain the correspondence of this cloned subtype, if any, to the native alpha 1-ARs defined by pharmacological criteria. In the present study, a partial alpha 1C-AR cDNA was obtained from rat cardiac… CONTINUE READING