Distribution of adenosine deaminase activity in rat brain and spinal cord.

@article{Geiger1986DistributionOA,
  title={Distribution of adenosine deaminase activity in rat brain and spinal cord.},
  author={Jonathan Geiger and J. I. Nagy},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={1986},
  volume={6 9},
  pages={2707-14}
}
The activity of adenosine deaminase (ADA) was measured in 62 discrete regions of the CNS, and in some autonomic and sensory ganglia, peripheral nerves, and peripheral tissues of the rat using an automated high-pressure liquid chromatography (HPLC) method. The formation of inosine and hypoxanthine as a measure of ADA activity in homogenates of brain was optimal at pH 7.0, linear for up to 60 min at 37 degrees C using 500 microM adenosine as substrate, and linear with protein concentrations… CONTINUE READING

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