Distribution of a novel mutation in the first exon of the human dopamine D4 receptor gene in psychotic patients

@article{Catalano1993DistributionOA,
  title={Distribution of a novel mutation in the first exon of the human dopamine D4 receptor gene in psychotic patients},
  author={Marco Catalano and Maria Nobile and Emanuela Novelli and Markus M. N{\"o}then and Enrico Smeraldi},
  journal={Biological Psychiatry},
  year={1993},
  volume={34},
  pages={459-464}
}
Disturbances in dopaminergic transmission have been implicated in the etiology of psychotic disorders. Interindividual differences in deoxyribonucleic acid (DNA) sequences coding for dopamine receptor proteins might contribute to the genetic background of these diseases. We have identified a variation in exon 1 of the dopamine D4 receptor (DRD4) gene, which is characterized by a polymorphic 12 base pair (bp) repeat. This repeat codes for a sequence of four amino acids in the extracellular N… Expand
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