Distribution of WDR 36 DNA Sequence Variants in Patients with Primary Open-Angle Glaucoma

@inproceedings{Hauser2006DistributionOW,
  title={Distribution of WDR 36 DNA Sequence Variants in Patients with Primary Open-Angle Glaucoma},
  author={Michael A. Hauser and R. Rand Allingham and Kevin Linkroum and Jun Wang and Karen R. Larocque-Abramson and Dayse M. Figueiredo and Cecilia Santiago-Turla and Elizabeth A. del Bono and Jonathan L. Haines and Margaret A. Pericak-Vance and Janey L. Wiggs},
  year={2006}
}
RESULTS. Thirty-two WDR36 sequence variants were found in this population of patients with POAG. Nonsynonymous singlenucleotide polymorphisms (SNPs), including those previously described as “disease-causing” and “disease susceptibility,” were found in 17% of POAG patients and 4% of control subjects. Although the distribution of WDR36 variants in the pedigrees did not show consistent segregation with the disease, the WDR36 sequence variants were found more frequently in patients with more severe… CONTINUE READING