Distribution of UVC-induced chromosome aberrations along the X chromosome of TCR deficient and proficient Chinese hamster cell lines.

@article{MrtinezLpez2010DistributionOU,
  title={Distribution of UVC-induced chromosome aberrations along the X chromosome of TCR deficient and proficient Chinese hamster cell lines.},
  author={Wilner M{\'a}rtinez-L{\'o}pez and Edvige Marotta and Mar{\'i}a Vittoria Di Tomaso and Leticia M{\'e}ndez-Acu{\~n}a and Fabrizio Palitti},
  journal={Mutation research},
  year={2010},
  volume={701 1},
  pages={98-102}
}
Cells with a transcription coupled repair (TCR) deficiency are characterized by a higher sensitivity to UVC irradiation and by an increase in apoptosis and chromosomal aberration frequencies. It has been claimed that the higher frequency of chromosomal aberrations results from the transcription blockage caused by UVC-lesions located in the transcribed strands of the genome. The distribution of chromosome breakpoints in euchromatic and heterochromatic regions of the X chromosome from TCR… CONTINUE READING

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