Distribution of Two Asian-Related Coding SNPs in the MC1R and OCA2 Genes

  title={Distribution of Two Asian-Related Coding SNPs in the MC1R and OCA2 Genes},
  author={Isao Yuasa and Kazuo Umetsu and Shinji Harihara and Akira Kido and Aya Miyoshi and Naruya Saitou and Bumbein Dashnyam and Feng Jin and G. Lucotte and Prasanta Kumar Chattopadhyay and Lotte Henke and J{\"u}rgen Henke},
  journal={Biochemical Genetics},
Very little is known about the genes and mechanisms affecting skin lightening in Asian populations. In this study, two coding SNPs, c.G1129A (R163Q) at the MC1R (melanocortin 1 receptor) gene and c.A1962G (H615R) at the OCA2 (oculocutaneous albinism type II) gene, were investigated in a total of 1,809 individuals in 16 populations from various areas. The Q163 and R615 alleles prevailed almost exclusively in East and Southeast Asian populations. Wright’s F ST was 0.445 for R163Q and 0.385 for… CONTINUE READING
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