Distribution of TRPVs, P2X3, and Parvalbumin in the Human Nodose Ganglion

  title={Distribution of TRPVs, P2X3, and Parvalbumin in the Human Nodose Ganglion},
  author={Daisuke Sato and Tadasu Sato and Yusuke Urata and Takayuki Okajima and Shota Kawamura and Manatsu Kurita and Kenta Takahashi and Masakazu Nanno and Asami Watahiki and Souichi Kokubun and Yoshinaka Shimizu and Eriko Kasahara and Noriaki Shoji and Takashi Sasano and Hiroyuki Ichikawa},
  journal={Cellular and Molecular Neurobiology},
Immunohistochemistry for several neurochemical substances, the transient receptor potential cation channel subfamily V member 1 (TRPV1) and 2 (TRPV2), P2X3 receptor, and parvalbumin (PV), was performed on the nodose ganglion, pharynx, and epiglottis in human cadavers. [] Key Method The nodose ganglion was situated beneath the jugular foramen, and had a spindle shape with the long rostrocaudal axis. The pharyngeal branch (PB) issued from a rostral quarter of the nodose ganglion, whereas the superior laryngeal…
Phenotypic distinctions between the nodose and jugular TRPV1-positive vagal sensory neurons in the cynomolgus monkey
Several key distinctions in gene expression between nodose and jugular TRPV1-positive (C-fiber) neurons that have been noted in mice, rats, and guinea pigs, are conserved in the cynomolgus monkey and support the translatability of distinct vagal C-fibers phenotypes to primates.
Localization of TRPV1 and P2X3 in unmyelinated and myelinated vagal afferents in the rat
Distribution of neuronal cells which contain dopamine β‐hydroxylase, tyrosine hydroxylase, neuropeptide Y and vasoactive intestinal polypeptide in the human internal carotid nerve
It is suggested that ICN neurons have a sympathetic function in the human and are significantly smaller than neuropeptide Y‐immunoreactive neurons in the ICN.
Characterization of a cell bridge variant connecting the nodose and superior cervical ganglia in the mouse: Prevalence, anatomical features, and practical implications
The anatomy of a cell bridge variant consisting of the fusion of the mouse NG and SCG, enriched in both markers of postganglionic sympathetic and vagal afferents neurons is described.
TRPA1s act as chemosensors but not as cold sensors or mechanosensors to trigger the swallowing reflex in rats
TRPA1s are functional and act as chemosensor, but not as cold sensors or mechanosensors, for triggering of the swallowing reflex, and a longer cold stimulus delays/prevents triggering of a reflex because of cold anesthesia.
Emx1-Cre is expressed in peripheral autonomic ganglia that regulate central cardiorespiratory functions
It is demonstrated that Emx1-IRES-Cre is expressed in the key peripheral autonomic nerve system and can modulate the cardiorespiratory function independently of forebrain expression, and the utility of this line to investigate the modulators of afferent vagal system is suggested.


The Distribution of TRPV1 and TRPV2 in the Rat Pharynx
Immunohistochemistry for two nociceptive transducers, the transient receptor potential cation channel subfamily V members 1 (TRPV1) and 2 (TRPV2), was performed on the pharynx and its adjacent
VR1-immunoreactive primary sensory neurons in the rat trigeminal ganglion
Immunocytochemical localization of the vanilloid receptor 1 (VR1): relationship to neuropeptides, the P2X3 purinoceptor and IB4 binding sites
Surprisingly, VR1‐ir did not coexist substantially in nerve fibres and terminals that contain substance P and calcitonin gene‐related peptide, suggesting complex mechanisms for the release of these neuropeptides in response to capsaicin application.
Co-expression of VRL-1 and calbindin D-28k in the rat sensory ganglia
The co-expression of VR1 and VRL-1 in the rat vagal sensory ganglia
Differential Expression of the mRNA for the Vanilloid Receptor Subtype 1 in Cells of the Adult Rat Dorsal Root and Nodose Ganglia and Its Downregulation by Axotomy
The data emphasize the heterogeneity of VR1 mRNA expression by subclasses of small sensory neurons, and this may result in their differential sensitivity to chemical and noxious heat stimuli, and also indicate that peripherally derived trophic factors may regulate levels ofVR1 mRNA.
The mechanosensitive nature of TRPV channels
In many nonsensory cells expressing TRPV4, such as vascular endothelial cells and renal tubular epithelial cells, the channel exhibits well-developed local mechanosensory transduction processes where both cell swelling and shear stress/fluid flow lead to channel activation.