Distribution of TRPVs, P2X3, and Parvalbumin in the Human Nodose Ganglion

@article{Sato2014DistributionOT,
  title={Distribution of TRPVs, P2X3, and Parvalbumin in the Human Nodose Ganglion},
  author={Daisuke Sato and Tadasu Sato and Yusuke Urata and Takayuki Okajima and Shota Kawamura and Manatsu Kurita and Kenta Takahashi and Masakazu Nanno and Asami Watahiki and Souichi Kokubun and Yoshinaka Shimizu and Eriko Kasahara and Noriaki Shoji and Takashi Sasano and Hiroyuki Ichikawa},
  journal={Cellular and Molecular Neurobiology},
  year={2014},
  volume={34},
  pages={851-858}
}
Immunohistochemistry for several neurochemical substances, the transient receptor potential cation channel subfamily V member 1 (TRPV1) and 2 (TRPV2), P2X3 receptor, and parvalbumin (PV), was performed on the nodose ganglion, pharynx, and epiglottis in human cadavers. [] Key Method The nodose ganglion was situated beneath the jugular foramen, and had a spindle shape with the long rostrocaudal axis. The pharyngeal branch (PB) issued from a rostral quarter of the nodose ganglion, whereas the superior laryngeal…
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TRPA1s act as chemosensors but not as cold sensors or mechanosensors to trigger the swallowing reflex in rats
TLDR
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Emx1-Cre is expressed in peripheral autonomic ganglia that regulate central cardiorespiratory functions
TLDR
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References

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The Distribution of TRPV1 and TRPV2 in the Rat Pharynx
Immunohistochemistry for two nociceptive transducers, the transient receptor potential cation channel subfamily V members 1 (TRPV1) and 2 (TRPV2), was performed on the pharynx and its adjacent
VR1-immunoreactive primary sensory neurons in the rat trigeminal ganglion
Immunocytochemical localization of the vanilloid receptor 1 (VR1): relationship to neuropeptides, the P2X3 purinoceptor and IB4 binding sites
TLDR
Surprisingly, VR1‐ir did not coexist substantially in nerve fibres and terminals that contain substance P and calcitonin gene‐related peptide, suggesting complex mechanisms for the release of these neuropeptides in response to capsaicin application.
Co-expression of VRL-1 and calbindin D-28k in the rat sensory ganglia
The co-expression of VR1 and VRL-1 in the rat vagal sensory ganglia
Differential Expression of the mRNA for the Vanilloid Receptor Subtype 1 in Cells of the Adult Rat Dorsal Root and Nodose Ganglia and Its Downregulation by Axotomy
TLDR
The data emphasize the heterogeneity of VR1 mRNA expression by subclasses of small sensory neurons, and this may result in their differential sensitivity to chemical and noxious heat stimuli, and also indicate that peripherally derived trophic factors may regulate levels ofVR1 mRNA.
The mechanosensitive nature of TRPV channels
TLDR
In many nonsensory cells expressing TRPV4, such as vascular endothelial cells and renal tubular epithelial cells, the channel exhibits well-developed local mechanosensory transduction processes where both cell swelling and shear stress/fluid flow lead to channel activation.
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