Distribution of TPMT risk alleles for thioupurine toxicity in the Israeli population

@article{Efrati2008DistributionOT,
  title={Distribution of TPMT risk alleles for thioupurine toxicity in the Israeli population},
  author={Edna Efrati and Lior Adler and Norberto Krivoy and Eli Sprecher},
  journal={European Journal of Clinical Pharmacology},
  year={2008},
  volume={65},
  pages={257-262}
}
Individuals with intermediate or no thiopurine S-methyltransferase (TPMT) activity are at risk of hematotoxicity when treated with standard doses of thiopurines, thus, pretreatment identification of these individuals is of major importance. The purpose of this study was to determine the frequency and distribution of TPMT polymorphic variants, known to functionally impair TPMT activity, in the highly heterogeneous Israeli population. TPMT genotyping of individuals representing three major… CONTINUE READING
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