Distribution of TGF-beta isoforms and signaling intermediates in corneal fibrotic wound repair.

Abstract

In this study, temporal and spatial distribution of three TGF-beta isoforms and their downstream signaling pathways including pSmad2 and p38MAPK were examined during fibrotic wound repair. In normal chick corneas, TGF-beta1, -2, and -3 were weakly detected in Bowman's layer (BL). In healing corneas, TGF-beta1 was primarily deposited in the fibrin clot and… (More)
DOI: 10.1002/jcb.22277

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